white matter

Corpus callosum involvement in language ability after left-hemispheric stroke

The left hemisphere (LH) is dominant for language in the majority of the healthy population. Patients with LH-damage may show global right-hemisphere (RH) activity for language. This makes interhemispheric transfer a good candidate for a brain …

Left temporal lobe language hubs – a comparative approach

The left temporal lobe is a major brain structure involved in language. Non-human primates, such as chimpanzees and bonobos, have language-like abilities and it has been argued that modifications to temporal lobe connectivity might have enabled …

Microstructural integrity of crucial white-matter tracts for category fluency in elderly with cerebral small vessel disease

Recent studies have suggested that language production abilities decline in patients with small vessel disease (SVD) a pathology that is one of the main contributors of cognitive impairment in older adults. The loss of microstructural integrity in …

How the speed of word finding depends on ventral tract integrity in primary progressive aphasia

Primary progressive aphasia (PPA) is a clinical neurodegenerative syndrome with word finding problems as a core clinical symptom. Many aspects of word finding have been clarified in psycholinguistics using picture naming and a picture-word …

The functional neuroanatomy of the left temporal lobe white matter – an interdisciplinary approach based on intraoperative and comparative studies.

The left temporal lobe is claimed to be involved in language comprehension in both the classical (Wernicke, 1874) and contemporary dual-pathway models for language processing (Hickok & Poeppel, 2007, Roelofs, 2014), but the role of neuroanatomical …

Investigating the semantic control network and its structural decline in mild cognitive impairment and mild dementia

Although the episodic and semantic memory systems have long been studied separately, recent literature revealed shared neural substrates, including the medial temporal lobe (MTL). One important aspect of semantic memory is semantic control, which …

The frontal aslant white matter tract (FAT) and semantic selection in word production

The frontal aslant tract (FAT) is a white matter structure joining the anterior supplementary and pre-supplementary motor area (SMA and pre-SMA) to the inferior and middle frontal gyri. FAT shows leftward asymmetry (Catani et al., 2012), which …

The role of the uncinate fasciculus and inferior longitudinal fasciculus in healthy and disordered language production

The role of ventral fiber pathways in healthy and disordered language production

While neuroimaging research on language production has traditionally focused primarily on grey matter, several recent studies highlight the involvement of ventral and dorsal white matter pathways. A debated issue concerns the exact functional role of …

White-matter bottleneck in small vessel disease: A lesion-symptom mapping study of executive-language functions

Cerebral small vessel disease (CSVD), characterized by the presence of white matter lesions (WML), is among the main causes of vascular cognitive impairment. The most well-studied cognitive domains showing impairment in CSVD are executive functioning …